Which rating must be met for a drug to be eligible for generic substitution?

For a drug to be eligible for generic substitution, it generally must be classified as "A rated." This classification indicates that the generic version is therapeutically equivalent to the brand-name drug, meaning it contains the same active ingredients and is intended for the same therapeutic effects. An "A rated" designation implies that both the generic and the brand-name drug can be expected to have the same efficacy and safety profile, thereby qualifying the generic for substitution at the pharmacy level.

In contrast, "B rated" drugs may not be considered therapeutically equivalent, as they might differ in formulation or release characteristics, making them unsuitable for substitution without specific conditions or physician approval. Ratings "C" and "D" also indicate various degrees of lack of approval or equivalence and would not support generic substitution as effectively as an "A rated" drug. Understanding this rating system is crucial for ensuring that patients receive the correct, safe, and effective medications they need.