What must be demonstrated for substances classified under Schedule II?

To classify a substance under Schedule II, it must be demonstrated that there are severe consequences for abuse. Schedule II substances have a high potential for abuse which can lead to severe psychological or physical dependence. This classification acknowledges that while these substances may have accepted medical uses—like certain opioids or stimulants—they are closely monitored due to the significant risks associated with their misuse.

The severity of consequences for abuse relates directly to the potential for addiction and the impact that misuse can have on individuals' health and wellbeing. Regulatory frameworks, such as the Controlled Substances Act, recognize these severe consequences and therefore regulate these substances strictly to mitigate risks.

The other answer choices do not fully encapsulate the critical factor for classification as a Schedule II substance. The notion of no risk of dependency (which is characteristic of lower schedules) and low medical use does not align with the high medical relevance yet substantial abuse potential that Schedule II substances embody. Furthermore, a moderate risk of dependence falls short of acknowledging the severe risks that indeed define this schedule. Thus, the correct understanding emphasizes the severe consequences associated with the abuse of these substances.